A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin
نویسندگان
چکیده
منابع مشابه
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin.
Histone lysine methylation is a central modification to mark functionally distinct chromatin regions. In particular, H3-K9 trimethylation has emerged as a hallmark of pericentric heterochromatin in mammals. Here we show that H4-K20 trimethylation is also focally enriched at pericentric heterochromatin. Intriguingly, H3-K9 trimethylation by the Suv39h HMTases is required for the induction of H4-...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2004
ISSN: 0890-9369
DOI: 10.1101/gad.300704